Can a single 22 pistol round be fatal?

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Of course it can be

yes , why shot one in your head of heart and find out .

Yes, most definitely...many people have been whacked with a 22.

Of course.

A shot to the heart or head could be fatal.

Sure.  Maybe not if you get shot in your left little toe, but in a vital area, it can cause death before you get help.

It can if it hits just the right place.  But a bone will stop a 22 round.  I assume if you were hit in the heart (between the ribs of course - it wouldn't go through the rib I don't think) it could kill you.  I believe a head shot where the skull is thin could kill also.  But it isn't easy unless you really know what you are doing.

It's still dangerous, because you never know.

Absolutely. It is a mistake to underestimate ANY firearm. In fact a .22 Long Rifle cartridge is used in many slaughter houses to kill IMMEDIATELY a 1200 pound cow for instance.

The Israeli Massad used the .22 LR in fact with propellant reduced for executions.

* even a blank cartridge (no bullet) has killed many

Yes a 22 bullet is a strange thing it can go right through you or it can go bouncing all three of your body leaving a trail of mass destruction. 

In most cases when a person is shot with a 22 the bullet travels all around inside the body cavity. 

It is absolutely true that 22 bullets kill more people than any other gun!  People don't think that a 22 can hurt you because it's so small. But a 22 can be a surgeon's worst nightmare. There have been cases with people getting shot with a 22 in the leg and have it travel up your leg and spin all around inside your guts and then exit through the shoulder. Leaving a wound channel that takes hours and hours to put together.

A 22 certainly does not have the takedown power of a big caliber bullet. You will bleed to death much slower.

But by the time the surgeon manages to close up the very long wound channel from a 22 there's a very good chance that you're going to die.

A single 22 hollow point to the back of the head is often fatal. At one time that was the way of performing an mob execution. A 22 was used at one time in slaughter houses (one round to the back of the head).